8 ms·

Which is caused by?

by superqwert 7y ago

Which is caused by?

deleted 7y ago
[deleted]
germinalphrase 7y ago
Despair
- dd36 7y ago
  And lax regulatory enforcement.
goldenkey 7y ago
Pain relief induced by pleasure and physical dependence - constipation too. I am almost off morphine. 15mg a day now. I have lost 30 lbs over 3 months. Chronic pain sucks but I despise opioids. They are seductive at first until one realizes their body is literally rotting away.. I was lifting 125lb dumbells before I got on morphine. Now I am feeble and haven't worked out in months. It kills your endogenous drive. If you care about your future self, please don't use opiates more than sparingly...
- superqwert 7y ago
  Well done, keep it going!
  - goldenkey 7y ago
    Thank you. Tapering at _just_ the right dose to not interfere with the grades in the master degree I am doing is quite tough. Which makes me wonder...there's common regimens like the Ashton scale and whatnot for benzos but it's very boilerplate. Unicorn Idea: Quantitative Withdrawal User enters dosage each time they use. Datetime is auto filled, but can be altered for dosages that are entered belatedly. ML is used to show charts with sliders based on speed of taper and severity of side effects. A time series showing the reduction in withdrawal effects over time with an ETA and other statistics. With labeled sections for certain parts of the withdrawal that are more severe (think a phase change diagram.) Seizure/epilespy zone would be clearly large on a configuration where the user chooses a ridiculously fast taper. The app would show a color, red in this case, warning of these symptoms and recommending against it. Baseline taper recommendations could be based on the medical literature out there with clinical trials. There is plenty of labeled data especially from the NIH. The user can log their current symptoms to help the model learn their individual brain chemistry. And vitals like HR, pulse, and o2 that are easily measured via pleasant APIs like Healthkit on iOS and Android. (Would be by proxy optionally compatible with iWatch, FitBit and other such sensors.) These vitals are great features that the model can learn from. The user can answer questions regarding the current state of their withdrawal symptoms, providing the model with labeled data to learn from. Models can be pretrained on an individual in close proximity to the MLE on the distribution of human neurochemistry. And thus would work out of the box pretty well before the users input and vitals start to vastly improve it until it helps the user maintain AND gain :-) just ideas..
    - superqwert 7y ago
      Great ideas - you should build a start-up!
      - goldenkey 7y ago
        Thank you. I would finish one if I had collaborators. Unfortunately I have virtually no friends.
        superqwert 7y ago
        What sort of collaborators are you looking for? What data + assets do you have to work with?
        goldenkey 7y ago
        Other devs. I do full stack. I don't have any training data, it was just an idea. Could probably develop it off of the metrics from my recovery.
- waterhouse 7y ago
  My mom said that, when recovering in the hospital from a certain operation, she was prescribed morphine for pain, and when she had some, "colors looked brighter, the air smelled sweeter, and everything just felt nicer"; when it wore off, she said, "Wooooow. So that's how drugs can be addictive." She refused all morphine after that.
  - goldenkey 7y ago
    Some people get that joy while others get nauseous upon first introduction to opioids. In any case, it's short lived, the honeymoon phase. Good on your mom - we will eventually get non-opioid, effective pain relievers. I am subbed to /r/drugnerds and there is a bit going on in the R and D of that area.
brohoolio 7y ago
Profits. Several drug manufacturers flooded the market with pills exposing way too many people to opioids in a casual way. Once folks are addicted it’s very very difficult to break the addiction. The Washington post has an excellent series on the topic if you are interested.
- Ididntdothis 7y ago
  From what I have read OxyContin was sold as needing only two doses a day. At that level it’s not that addictive. But it soon turned out that two times a day is not enough so people took more to avoid crashing in between. With that amount it became very addictive but companies still kept selling the two doses a day although they knew that people would quickly take more.
  - pkaye 7y ago
    The whole point of OxyCotin was that it was a long acting dose. So if they admitted it didn't last that long it would cause loss of business. This cause a lot of patients to be undertreated and seek alternatives.
overdosing 7y ago
The abuse of drugs, often acquired illegally. Listen, if this is going to be The Five Whys, save it for a preachier audience, prone to emotion. Opiate use is not a concept that fits inside 140 characters. The most stunning reality, regarding the opioid epidemic is that it came hot on the heels of the incredible ravages of the methamphetamine/crystal meth wave that shredded many parts of the U.S. only a few short years ago. People use the drugs because they catch a taste, and are shocked by the realization that they like it. It's suddenly not the spectre of evil, when a familiar acquaintance turns you onto something in a relaxed atmosphere. And it keeps happening, and it spreads, and spreads, and spreads. Because there's an unrestricted supply. Legal or not. People make it happen. The people who acquire that taste pull hard, and the people who make money push it on them even harder. The power structure that sits atop it all is a mountain range, with many peaks. Some peaks are beyond U.S. borders, in Mexico, China, Afghanistan. Some of it started with the global war on terror and the hunt for Osama Bin Laden, but we're way beyond that now, and the epidemic is a raging forrest fire, when considering the lit cigarette of Islamic terror flicked into the dry field of Afghan tinder back in 2002. New pills. New companies. A dehumanizing internet. Asocial people staring at smart phones, playing video games, avoiding human interaction in real life. Joblessness amid celebrity. Broken social norms. Ruined financial stature. Warped perception of peers and status. Both hopelessness and hopeful promise in equal measure, and drugs to help to forget the bad time and feel good, through it all, even if artificially. One could write volumes. One could craft the career of a historian, regaling heraldry of a decade's new nightmare wasteland as people check out from a lifetime of broken promises by disintegrated peers, anesthetized by milk of the poppy.

Which is caused by?

deleted 7y ago

[deleted]

germinalphrase 7y ago

Despair

dd36 7y ago
And lax regulatory enforcement.

goldenkey 7y ago

Pain relief induced by pleasure and physical dependence - constipation too. I am almost off morphine. 15mg a day now. I have lost 30 lbs over 3 months. Chronic pain sucks but I despise opioids. They are seductive at first until one realizes their body is literally rotting away.. I was lifting 125lb dumbells before I got on morphine. Now I am feeble and haven't worked out in months. It kills your endogenous drive. If you care about your future self, please don't use opiates more than sparingly...

superqwert 7y ago
Well done, keep it going!
- goldenkey 7y ago
  Thank you. Tapering at _just_ the right dose to not interfere with the grades in the master degree I am doing is quite tough. Which makes me wonder...there's common regimens like the Ashton scale and whatnot for benzos but it's very boilerplate. Unicorn Idea: Quantitative Withdrawal User enters dosage each time they use. Datetime is auto filled, but can be altered for dosages that are entered belatedly. ML is used to show charts with sliders based on speed of taper and severity of side effects. A time series showing the reduction in withdrawal effects over time with an ETA and other statistics. With labeled sections for certain parts of the withdrawal that are more severe (think a phase change diagram.) Seizure/epilespy zone would be clearly large on a configuration where the user chooses a ridiculously fast taper. The app would show a color, red in this case, warning of these symptoms and recommending against it. Baseline taper recommendations could be based on the medical literature out there with clinical trials. There is plenty of labeled data especially from the NIH. The user can log their current symptoms to help the model learn their individual brain chemistry. And vitals like HR, pulse, and o2 that are easily measured via pleasant APIs like Healthkit on iOS and Android. (Would be by proxy optionally compatible with iWatch, FitBit and other such sensors.) These vitals are great features that the model can learn from. The user can answer questions regarding the current state of their withdrawal symptoms, providing the model with labeled data to learn from. Models can be pretrained on an individual in close proximity to the MLE on the distribution of human neurochemistry. And thus would work out of the box pretty well before the users input and vitals start to vastly improve it until it helps the user maintain AND gain :-) just ideas..
  - superqwert 7y ago
    Great ideas - you should build a start-up!
    - goldenkey 7y ago
      Thank you. I would finish one if I had collaborators. Unfortunately I have virtually no friends.
      - superqwert 7y ago
        What sort of collaborators are you looking for? What data + assets do you have to work with?
        goldenkey 7y ago
        Other devs. I do full stack. I don't have any training data, it was just an idea. Could probably develop it off of the metrics from my recovery.
waterhouse 7y ago
My mom said that, when recovering in the hospital from a certain operation, she was prescribed morphine for pain, and when she had some, "colors looked brighter, the air smelled sweeter, and everything just felt nicer"; when it wore off, she said, "Wooooow. So that's how drugs can be addictive." She refused all morphine after that.
- goldenkey 7y ago
  Some people get that joy while others get nauseous upon first introduction to opioids. In any case, it's short lived, the honeymoon phase. Good on your mom - we will eventually get non-opioid, effective pain relievers. I am subbed to /r/drugnerds and there is a bit going on in the R and D of that area.

brohoolio 7y ago

Profits. Several drug manufacturers flooded the market with pills exposing way too many people to opioids in a casual way. Once folks are addicted it’s very very difficult to break the addiction. The Washington post has an excellent series on the topic if you are interested.

Ididntdothis 7y ago
From what I have read OxyContin was sold as needing only two doses a day. At that level it’s not that addictive. But it soon turned out that two times a day is not enough so people took more to avoid crashing in between. With that amount it became very addictive but companies still kept selling the two doses a day although they knew that people would quickly take more.
- pkaye 7y ago
  The whole point of OxyCotin was that it was a long acting dose. So if they admitted it didn't last that long it would cause loss of business. This cause a lot of patients to be undertreated and seek alternatives.

overdosing 7y ago

The abuse of drugs, often acquired illegally. Listen, if this is going to be The Five Whys, save it for a preachier audience, prone to emotion. Opiate use is not a concept that fits inside 140 characters. The most stunning reality, regarding the opioid epidemic is that it came hot on the heels of the incredible ravages of the methamphetamine/crystal meth wave that shredded many parts of the U.S. only a few short years ago. People use the drugs because they catch a taste, and are shocked by the realization that they like it. It's suddenly not the spectre of evil, when a familiar acquaintance turns you onto something in a relaxed atmosphere. And it keeps happening, and it spreads, and spreads, and spreads. Because there's an unrestricted supply. Legal or not. People make it happen. The people who acquire that taste pull hard, and the people who make money push it on them even harder. The power structure that sits atop it all is a mountain range, with many peaks. Some peaks are beyond U.S. borders, in Mexico, China, Afghanistan. Some of it started with the global war on terror and the hunt for Osama Bin Laden, but we're way beyond that now, and the epidemic is a raging forrest fire, when considering the lit cigarette of Islamic terror flicked into the dry field of Afghan tinder back in 2002. New pills. New companies. A dehumanizing internet. Asocial people staring at smart phones, playing video games, avoiding human interaction in real life. Joblessness amid celebrity. Broken social norms. Ruined financial stature. Warped perception of peers and status. Both hopelessness and hopeful promise in equal measure, and drugs to help to forget the bad time and feel good, through it all, even if artificially. One could write volumes. One could craft the career of a historian, regaling heraldry of a decade's new nightmare wasteland as people check out from a lifetime of broken promises by disintegrated peers, anesthetized by milk of the poppy.