5 ms·

Probably because most data disagree with this comment. There's a ~20% relative risk reduction in vascular events & mortality per ~40 mg/dL decrease in LDL. The

Probably because most data disagree with this comment. There's a ~20% relative risk reduction in vascular events & mortality per ~40 mg/dL decrease in LDL. The CTT is probably the best summary of these data: https://www.cttcollaboration.org/ https://www.cttcollaboration.org/

virtuallynathan 7y ago
> "~20% relative risk reduction in vascular events & mortality per ~40 mg/dL decrease in LDL." Is that a composite endpoint of vascular events AND mortality? From TheNNT: "It takes 5 years of daily statin therapy to achieve a 1.6% chance of avoiding a heart attack, and a 0.37% chance of avoiding a stroke. Most disappointing, statins seem unable to prevent death in this group. And most concerning, the drugs may increase diabetes, a serious and life-altering disease." (Primary Prevention) http://www.thennt.com/nnt/statins-for-heart-disease-prevention-without-prior-heart-disease-2/ http://www.thennt.com/nnt/statins-for-heart-disease-preventi...
village-idiot 7y ago
That would be the same CTT that makes money from the makers of Statins and has been accused of being insufficiently transparent around their studies[0]. 0 http://www.drjohnm.org/2014/06/growing-doubt-on-statin-drugs-the-problem-of-drug-lifestyle-interaction/ http://www.drjohnm.org/2014/06/growing-doubt-on-statin-drugs...
deleted 7y ago
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