6 ms·

There’s a ton of research online... https://dancesafe.org/drug-information/is-mdma-neurotoxic/ https://dancesafe.org/drug-information/is-mdma-neurotoxic/

deleted 7y ago
[deleted]
ggm 7y ago
Thats incredibly scary reading.
- beenBoutIT 7y ago
  The good news is that MDMA(along with plenty of other interesting phenylethylamines) isn't neurotoxic . All the hysteria was the result of bad science and there's actually evidence that MDMA use might improve sleep efficiency. http://www.maps.org/news-letters/v06n1/06108neu.html http://www.maps.org/news-letters/v06n1/06108neu.html
  - temp99990 7y ago
    Are you really citing a paper from 1995? I mean I’m a user of illegal drugs and would rather be safe than sorry. If you look at the mechanics of MDMA, it’s basically forcing your brain to release serotonin from the floodgates in a way that can damage neurons. Drug tolerance is real. Personally I’d rather be safe than sorry.
    - snowwindwaves 7y ago
      In some fields the best papers are the oldest ones and all subsequent work adds basically nothing except someone got a phd out of it. Give old and original research a chance, it is often very high quality.
    - beenBoutIT 7y ago
      Look into Alexander Shulgin and other intelligent old people who've openly used MDMA for decades and you won't see a lot of obvious brain damage.
  - the_gipsy 7y ago
    I thought it was definitely neurotoxic IF used at high frequency and/or dosage. Be careful with dismissing the warnings as hysteria. Enjoy MDMA responsibly: right dosage and long periods between. This also happens to make the experience much, much better :)
- stickfigure 7y ago
  The money shot in the conclusion is: Although common recreational doses of MDMA don’t seem to be neurotoxic, it’s important to practice moderation. I wouldn't call that "incredibly scary", more like "concerning".
  - ggm 7y ago
    I don't do pills. When I did do things, long long ago in another galaxy, behind the statute of limitations veil, I don't recall people being very good about not doing things to excess. Also, I am told a constant issue with pills is dosage is deeply uncertain, hence the MDMA deaths issue at Australian festivals, and the pressure for pill testing.
    - roel_v 7y ago
      "Also, I am told a constant issue with pills is dosage is deeply uncertain, hence the MDMA deaths issue at Australian festivals" I'll admit I haven't kept up with the research since I stopped going to house (now known as 'EDM' apparently) parties 20 years ago, but back then it was well known that 'mdma deaths' were actually people dying of dehydration or because of hearth issues due to combining mdma with other drugs. What's the status today? Do people actually die from mdma itself, or just in circumstances where mdma is involved?
      - ggm 7y ago
        I don't know. It's not my scene. It's probably contamination.
tempguy9999 7y ago
from the paper > Animal research suggests that when a neurotoxic dosage of MDMA is given, damage to the axons starts to occur in as little as an hour or two So when neurotoxic doses are administered, neurotoxicity occurs. Well, call the president, we must do something. Please read the link I posted above, here again <https://thedea.org/mdma-risks-science-and-statistics-technical-faq/mdma-ecstasy-molly-neurotoxicity-brain-damage/> https://thedea.org/mdma-risks-science-and-statistics-technic... which largely debunks this work, although it does offer situations where it does occur, so you can avoid them. If you want to talk actual neurotoxic, methamphetamine is to be, and I've seen the effects on a guy I know. But stop putting about FUD about MDMA. Edit: I re-read the link properly and it's not as bad as I first thought. It mentions that research by Ricaurte was debunked. My link goes into a lot more detail of what happened, read especially the last couple of pages where Ricaurte's research is entertainingly debunked in a letter to Science magazine. Edit2: from my link, regarding MDMA neurotoxicity: "More than a year later, after scathing criticism from TheDEA.org, the house of cards collapsed when Ricaurte sheepishly admitted that the experiment never really happened: The monkeys had actually been given massive doses of methampetamine, not MDMA! He also admitted that no matter what they had tried, they had been unable to damage monkey’s dopamine systems with real MDMA"

deleted 7y ago

[deleted]

ggm 7y ago

Thats incredibly scary reading.

beenBoutIT 7y ago
The good news is that MDMA(along with plenty of other interesting phenylethylamines) isn't neurotoxic . All the hysteria was the result of bad science and there's actually evidence that MDMA use might improve sleep efficiency. http://www.maps.org/news-letters/v06n1/06108neu.html http://www.maps.org/news-letters/v06n1/06108neu.html
- temp99990 7y ago
  Are you really citing a paper from 1995? I mean I’m a user of illegal drugs and would rather be safe than sorry. If you look at the mechanics of MDMA, it’s basically forcing your brain to release serotonin from the floodgates in a way that can damage neurons. Drug tolerance is real. Personally I’d rather be safe than sorry.
  - snowwindwaves 7y ago
    In some fields the best papers are the oldest ones and all subsequent work adds basically nothing except someone got a phd out of it. Give old and original research a chance, it is often very high quality.
  - beenBoutIT 7y ago
    Look into Alexander Shulgin and other intelligent old people who've openly used MDMA for decades and you won't see a lot of obvious brain damage.
- the_gipsy 7y ago
  I thought it was definitely neurotoxic IF used at high frequency and/or dosage. Be careful with dismissing the warnings as hysteria. Enjoy MDMA responsibly: right dosage and long periods between. This also happens to make the experience much, much better :)
stickfigure 7y ago
The money shot in the conclusion is: Although common recreational doses of MDMA don’t seem to be neurotoxic, it’s important to practice moderation. I wouldn't call that "incredibly scary", more like "concerning".
- ggm 7y ago
  I don't do pills. When I did do things, long long ago in another galaxy, behind the statute of limitations veil, I don't recall people being very good about not doing things to excess. Also, I am told a constant issue with pills is dosage is deeply uncertain, hence the MDMA deaths issue at Australian festivals, and the pressure for pill testing.
  - roel_v 7y ago
    "Also, I am told a constant issue with pills is dosage is deeply uncertain, hence the MDMA deaths issue at Australian festivals" I'll admit I haven't kept up with the research since I stopped going to house (now known as 'EDM' apparently) parties 20 years ago, but back then it was well known that 'mdma deaths' were actually people dying of dehydration or because of hearth issues due to combining mdma with other drugs. What's the status today? Do people actually die from mdma itself, or just in circumstances where mdma is involved?
    - ggm 7y ago
      I don't know. It's not my scene. It's probably contamination.

tempguy9999 7y ago

from the paper > Animal research suggests that when a neurotoxic dosage of MDMA is given, damage to the axons starts to occur in as little as an hour or two So when neurotoxic doses are administered, neurotoxicity occurs. Well, call the president, we must do something. Please read the link I posted above, here again <https://thedea.org/mdma-risks-science-and-statistics-technical-faq/mdma-ecstasy-molly-neurotoxicity-brain-damage/> https://thedea.org/mdma-risks-science-and-statistics-technic... which largely debunks this work, although it does offer situations where it does occur, so you can avoid them. If you want to talk actual neurotoxic, methamphetamine is to be, and I've seen the effects on a guy I know. But stop putting about FUD about MDMA. Edit: I re-read the link properly and it's not as bad as I first thought. It mentions that research by Ricaurte was debunked. My link goes into a lot more detail of what happened, read especially the last couple of pages where Ricaurte's research is entertainingly debunked in a letter to Science magazine. Edit2: from my link, regarding MDMA neurotoxicity: "More than a year later, after scathing criticism from TheDEA.org, the house of cards collapsed when Ricaurte sheepishly admitted that the experiment never really happened: The monkeys had actually been given massive doses of methampetamine, not MDMA! He also admitted that no matter what they had tried, they had been unable to damage monkey’s dopamine systems with real MDMA"