What AFL needs is _instrumentation_ and of course the easiest way is to get that at compilation step, however you are not constrained by anything to get that pa

What AFL needs is _instrumentation_ and of course the easiest way is to get that at compilation step, however you are not constrained by anything to get that part via other means. Check https://github.com/ivanfratric/winafl https://github.com/ivanfratric/winafl that uses DynamoRIO. So, to answer your question -- it wouldn't be easy but it can be done.