Maybe (I don't study this) but at least some of this pathway is also used in embryonic cells, so it's pretty fundamental. More often, cancer cells will evolve r

Maybe (I don't study this) but at least some of this pathway is also used in embryonic cells, so it's pretty fundamental. More often, cancer cells will evolve resistance to whatever inhibitor molecule is targeting them, i.e. mutate so the ligand doesn't bind as well.