I figured it out after a few minutes poking around. You'll need some way to set "secure" settings – if you're not rooted, the easiest way is via a Tasker plugi

I figured it out after a few minutes poking around. You'll need some way to set "secure" settings – if you're not rooted, the easiest way is via a Tasker plugin called AutoTools. Once you've set that up, create a task with an action of "AutoTools Secure Settings", then configure it as follows (under "Custom Setting" in the AutoTools menu): - setting type: secure - name: accessibility_display_daltonizer_enabled - input type: toggle - value: 3 That task then toggles greyscale mode, so you can hook it up to an application context or whatever. (Switch the value to 1 if you want a task that always enables greyscale, or 2 to always disable.) If it doesn't work, diff the output of `adb shell settings list secure` from a PC with greyscale mode enabled and disabled, and use whatever name you get there.