We haven't tried using gRPC in Python, as we have completely migrated from Python away towards Go. Our experience of using gRPC in Java, C++ and Golang is pret

We haven't tried using gRPC in Python, as we have completely migrated from Python away towards Go. Our experience of using gRPC in Java, C++ and Golang is pretty good. While it had some initial teething issues (when it was first released), the libraries have generally been a non-issue since the gRPC General Availability (GA-1.0 version). If you're considering using it in Go, check out the https://github.com/grpc-ecosystem/go-grpc-middleware https://github.com/grpc-ecosystem/go-grpc-middleware helper libraries that we've contributed back to gRPC Ecosystem.