If I'm understanding your question, your most viable choices are wxPython or PyQt/PySide. For getting it into an .exe, look at PyInstaller (failing that, py2exe

If I'm understanding your question, your most viable choices are wxPython or PyQt/PySide. For getting it into an .exe, look at PyInstaller (failing that, py2exe). If by "drag-drop interface" you mean a friendly UI design tool (in the mold of Visual Studio), IMHO there are no good choices.